Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells

@article{2015SynergisticSE,
  title={Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells},
  author={Bin-yong Liang 梁宾勇 and 熊敏 MinXiong and Gui-bao Ji 纪桂宝 and Er-lei Zhang 张二雷 and Zun-yi Zhang 张尊义 and Ke-shuai Dong 董可帅 and Xiao-ping Chen 陈孝平 and Zhi-yong Huang 黄志勇},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2015},
  volume={35},
  pages={535-540}
}
Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors and histone deacetylase (HDAC) inhibitors have recently emerged as promising anticancer drugs. The aim of this study was to investigate the effect of combination treatment with the PARP inhibitor PJ34 and HDAC inhibitor SAHA on the proliferation of liver cancer cells. Cell proliferation and apoptosis were assessed in three human liver cancer cell lines (HepG2, Hep3B and HCC-LM3) treated with PJ34 (8 μmol/L) and SAHA (1 μmol/L), alone or… CONTINUE READING
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