Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes.

@article{Agresti1998SynergisticSO,
  title={Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes.},
  author={Cristina Agresti and Antonietta Bernardo and N Del Russo and Giovanna Marziali and Angela Battistini and Francesca Aloisi and Giulio Levi and Eliana M Coccia},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 9},
  pages={2975-83}
}
In order to understand the molecular basis of the synergistic action of interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) on rat oligodendrocyte development, we studied some aspects of the signalling pathways involved in the regulation of the major histocompatibility complex (MHC) class I and the interferon regulatory factor 1 (IRF-1) gene expression. Two well-defined inducible enhancers of the MHC class I gene promoter, the MHC class I regulatory element (MHC-CRE) and… CONTINUE READING
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