Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.

@article{Kim2010SynergisticSF,
  title={Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.},
  author={Hun Sik Kim and Asmita Das and Catharina Christiane Gro\ss and Yenan T Bryceson and Eric O Long},
  journal={Immunity},
  year={2010},
  volume={32 2},
  pages={175-86}
}
Natural killer (NK) cell cytotoxicity toward target cells depends on synergistic coactivation by NK cell receptors such as NKG2D and 2B4. How synergy occurs is not known. Synergistic phosphorylation of phospholipase PLC-gamma2, Ca(2+) mobilization, and degranulation triggered by NKG2D and 2B4 coengagement were blocked by Vav1 siRNA knockdown, but enhanced by knockdown of c-Cbl. c-Cbl inhibited Vav1-dependent signals, given that c-Cbl knockdown did not rescue the Vav1 defect. Moreover, c-Cbl… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…