Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3',5'-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopio

@article{Mynard2004SynergisticSB,
  title={Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3',5'-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopio},
  author={Vanessa Mynard and Olivier Latchoumanin and Laurence Guignat and Jocelyne Devin-Leclerc and Xavier Y Bertagna and Benjamin Barr{\'e} and J{\'e}r{\^o}me Fagart and Olivier Coqueret and Maria Grazia Catelli},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 12},
  pages={
          2997-3010
        }
}
Leukemia inhibitory factor (LIF) cooperates with CRH at the pituitary level to induce POMC gene transcription, resulting in activation of the pituitary-adrenal axis. However, the underlying molecular mechanisms remain elusive. Here, we show that the NurRE-signal transducers and activators of transcription (STAT) composite element of the POMC promoter was the predominant target of the LIF-CRH synergy. Whereas NurRE or STAT sites alone conferred synergy, the maximal response was found with the… CONTINUE READING

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- restricted T box factor , Tpit , activates POMC transcription in cooperation with Pitx homeoproteins

  • M Maira, C Couture, G LeMartelot, AM Pulichino, S Bilodeau, J Drouin
  • 2003