Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.

@article{Schwartz2011SynergisticRO,
  title={Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.},
  author={Erica S. Schwartz and Julie A Christianson and Xiaowei Chen and Jun-Ho La and Brian M. Davis and Kathryn M Albers and Gerald F. Gebhart},
  journal={Gastroenterology},
  year={2011},
  volume={140 4},
  pages={
          1283-1291.e1-2
        }
}
BACKGROUND & AIMS The transient receptor potential (TRP) channels TRPV1 and TRPA1 have each been associated with regulation of efferent properties of primary afferent neurons that initiate neurogenic inflammation and are required for the development of inflammatory hyperalgesia. To evaluate the role of these channels in producing pain during pancreatic inflammation, we studied pancreatic nodose ganglion (NG) and dorsal root ganglion (DRG) sensory neurons (identified by content of retrograde… CONTINUE READING
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