Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.

@article{Ross1994SynergisticRO,
  title={Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.},
  author={Douglas D. Ross and P J Wooten and Yu Tong and Barbara A. Cornblatt and Carmit Levy and Rajeshwari Sridhara and Edward J. Lee and Charles A Schiffer},
  journal={Blood},
  year={1994},
  volume={83 5},
  pages={1337-47}
}
Cremophor (Crem) EL, the vehicle for intravenous delivery of cyclosporin A (CsA), has been reported to counteract multidrug resistance (MDR) in P-glycoprotein (Pgp)-over-expressing cell lines. Because of this, we sought to determine whether Crem functions independently as a modulator of MDR in blast cells obtained from acute myelogenous leukemia (AML) patients, and the nature of its interaction in combination with CsA in reversing an MDR phenotype. In the phenotypically classical MDR AML cell… CONTINUE READING

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