Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.

@article{Heanue1999SynergisticRO,
  title={Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.},
  author={Tiffany A Heanue and Ram Reshef and Richard J. Davis and Graeme Mardon and Guillermo Oliver and Stanislav I. Tomarev and Andrew B. Lassar and Clifford J Tabin},
  journal={Genes & development},
  year={1999},
  volume={13 24},
  pages={3231-43}
}
We have identified a novel vertebrate homolog of the Drosophila gene dachshund, Dachshund2 (Dach2). Dach2 is expressed in the developing somite prior to any myogenic genes with an expression profile similar to Pax3, a gene previously shown to induce muscle differentiation. Pax3 and Dach2 participate in a positive regulatory feedback loop, analogous to a… CONTINUE READING