Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice.

@article{AbdelDaim2015SynergisticPR,
  title={Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice.},
  author={Mohamed M. Abdel-Daim and Emad W. Ghazy and Mostafa Fayez},
  journal={Canadian journal of physiology and pharmacology},
  year={2015},
  volume={93 1},
  pages={
          45-51
        }
}
Tilmicosin (TIL) is a long-acting macrolide antibiotic approved for the treatment of cattle with Bovine Respiratory Disease. However, overdose of TIL has been reported to induce cardiotoxicity. The purpose of our experiment was to evaluate the protective effects of Commiphora molmol (mirazid (MRZ); myrrh) and (or) ascorbic acid (AA) against TIL-induced cardiotoxicity in mice. MRZ and AA were orally administered using stomach gavage, either alone or in combination for 5 consecutive days… 

Protective effect of Terminalia muelleri against carbon tetrachloride-induced hepato and nephro-toxicity in mice and characterization of its bioactive constituents

TMEF has a marked hepato-nephro protective effect against CCl4-induced toxicity in mice and preserved the hepatic architecture and protected from ballooning degeneration, liver necrosis, renal inflammation, and degeneration of the kidney tubules.

Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice

BHPF has a remarkable hepato- and nephroprotective activity by enhancing the antioxidant defense status, reducing lipid peroxidation and protecting against the histopathological changes induced by CCl4 in the liver and kidney tissues.

Protective Effects of Mirazid on Gentamicin-induced Nephrotoxicity in Rats through Antioxidant, Anti-inflammatory, JNK1/ iNOS, and Apoptotic Pathways; Novel Mechanistic Insights

Mirazid represented a viable approach to suppress the nephrotoxicity produced by Gentamycin through inhibiting JNK1/ iNOS pathways, thus preserving kidney function and restoring oxidant/antioxidant hemostasis.

Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice

DFS could potentiate the cardiotoxic effects of tulathromycin, whereas lycopene can serve as a cardioprotective agent against DFS and tulATHromycin.

Cardiotoxicity and myocardial infarction‐associated DNA damage induced by thiamethoxam in vitro and in vivo: Protective role of Trigonella foenum‐graecum seed‐derived polysaccharide

FWEP provided significant protection against TMX‐induced heart injury, and could be a useful and efficient agent against cardiotoxicity and atherosclerosis.

Repeated dose of meloxicam induces genotoxicity and histopathological changes in cardiac tissue of mice

Meloxicam at the dose prescribed for small animals could potentially cause cardiac histopathologic alterations and genotoxic effects.

Protective Effects of Diallyl Sulfide and Curcumin Separately against Thallium-Induced Toxicity in Rats

DAS and curcumin effectively reduced TI-induced liver toxicity and total antioxidant capacity (TAC) in rats and reversed the changes in most studied biochemical parameters.

Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

This study shows that both carvedilol and vitamin C protect against azithromycin-induced cardiotoxicity through antioxidant, immunomodulatory, and antiapoptotic mechanisms.

References

SHOWING 1-10 OF 44 REFERENCES

Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion.

Lack of the Beneficial Effects of Mirazid (Commiphora molmol) When administered with Chemotherapeutic Agents on Ehrlich Ascetic Carcinoma Bearing Mice

Assessment of the efficacy of oleo-gum-resin of Commiphora molmol and the commercial extract known as Mirazid as anti-tumor agents and its possible role as a complementary medicine with the standard chemotherapeutic drugs; cisplatin or 5-Flurouracil was conducted.

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

It could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

It could be concluded that spirulina administration able to minimize the toxic effects of deltamethrin by its free radical-scavenging and potent antioxidant activity.

Hepatoprotective and Antioxidant Activity of Dunaliella salina in Paracetamol-induced Acute Toxicity in Rats

Results suggest that D. salina exhibits a potent hepatoprotective effect on paracetamol-induced liver damage in rats, which may be due to both the increase of antioxidant enzymes activity and inhibition of lipid peroxidation.

Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS

It is suggested that a dietary supplement of BHE could exert a beneficial effect against oxidative stress and various liver diseases by enhancing the antioxidant defense status, reducing lipid peroxidation, and protecting against the pathological changes of the liver.

The effect of ascorbic acid supplementation on endosulfan toxicity in rabbits

An increased and progressively uncompensated oxidant stress in endosulfan-administered rabbits was substantially ameliorated by vitamin C supplementation through an improvement in antioxidant capacity.

Protective effect of guggulsterone against cardiomyocyte injury induced by doxorubicin in vitro

The protective effects of guggulsterone (GS), a steroid obtained from myrrh, are evaluated to determine its preliminary mechanisms in defending against DOX-induced cytotoxicity in H9C2 cells and provide considerable evidence that GS could serve as a novel cardioprotective agent against DOx-induced cardiotoxicity.

Protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice.

Turmeric and myrrh are useful herbal remedies, especially for controlling oxidative damages and genotoxicity induced by lead acetate intoxication, and the powerful protection was observed with 5% powdered turmeric.

Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs.

The data indicate that toxic doses of TM may have a negative inotropic effect in conscious dogs and that treatment with propranolol or dobutamine HCl reversed some, but not all, of the effects caused by TM administration.