Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice.

@article{AbdelDaim2015SynergisticPR,
  title={Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice.},
  author={Mohamed M. Abdel-Daim and Emad W. Ghazy and Mostafa Fayez},
  journal={Canadian journal of physiology and pharmacology},
  year={2015},
  volume={93 1},
  pages={
          45-51
        }
}
Tilmicosin (TIL) is a long-acting macrolide antibiotic approved for the treatment of cattle with Bovine Respiratory Disease. However, overdose of TIL has been reported to induce cardiotoxicity. The purpose of our experiment was to evaluate the protective effects of Commiphora molmol (mirazid (MRZ); myrrh) and (or) ascorbic acid (AA) against TIL-induced cardiotoxicity in mice. MRZ and AA were orally administered using stomach gavage, either alone or in combination for 5 consecutive days… 
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29 Citations

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References

SHOWING 1-10 OF 44 REFERENCES

Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion.

Lack of the Beneficial Effects of Mirazid (Commiphora molmol) When administered with Chemotherapeutic Agents on Ehrlich Ascetic Carcinoma Bearing Mice

Assessment of the efficacy of oleo-gum-resin of Commiphora molmol and the commercial extract known as Mirazid as anti-tumor agents and its possible role as a complementary medicine with the standard chemotherapeutic drugs; cisplatin or 5-Flurouracil was conducted.

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

It could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

It could be concluded that spirulina administration able to minimize the toxic effects of deltamethrin by its free radical-scavenging and potent antioxidant activity.

Hepatoprotective and Antioxidant Activity of Dunaliella salina in Paracetamol-induced Acute Toxicity in Rats

Results suggest that D. salina exhibits a potent hepatoprotective effect on paracetamol-induced liver damage in rats, which may be due to both the increase of antioxidant enzymes activity and inhibition of lipid peroxidation.

Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS

It is suggested that a dietary supplement of BHE could exert a beneficial effect against oxidative stress and various liver diseases by enhancing the antioxidant defense status, reducing lipid peroxidation, and protecting against the pathological changes of the liver.

The effect of ascorbic acid supplementation on endosulfan toxicity in rabbits

An increased and progressively uncompensated oxidant stress in endosulfan-administered rabbits was substantially ameliorated by vitamin C supplementation through an improvement in antioxidant capacity.

Protective effect of guggulsterone against cardiomyocyte injury induced by doxorubicin in vitro

The protective effects of guggulsterone (GS), a steroid obtained from myrrh, are evaluated to determine its preliminary mechanisms in defending against DOX-induced cytotoxicity in H9C2 cells and provide considerable evidence that GS could serve as a novel cardioprotective agent against DOx-induced cardiotoxicity.

Protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice.

Turmeric and myrrh are useful herbal remedies, especially for controlling oxidative damages and genotoxicity induced by lead acetate intoxication, and the powerful protection was observed with 5% powdered turmeric.

Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs.

The data indicate that toxic doses of TM may have a negative inotropic effect in conscious dogs and that treatment with propranolol or dobutamine HCl reversed some, but not all, of the effects caused by TM administration.