Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats

@inproceedings{AbdelWahab2017SynergisticPE,
  title={Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats},
  author={Wessam M. Abdel-Wahab and Farouzia I Moussa and Najwa A Saad},
  booktitle={Drug design, development and therapy},
  year={2017}
}
  • Wessam M. Abdel-Wahab, Farouzia I Moussa, Najwa A Saad
  • Published in
    Drug design, development and…
    2017
  • Medicine
  • Cisplatin (cis-diaminedichloroplatinum II; CDDP) is an effective anticancer drug, but it has limitations because of its nephrotoxicity. This study investigates the protective effect of N-acetylcysteine (NAC) and taurine (TAU), both individually and in combination, against CDDP nephrotoxicity in rats. For this purpose, 48 male rats were assigned into eight groups (n=6) as follows: 1) control group, 2) NAC group, 3) TAU group, 4) NAC-TAU group, 5) CDDP group, 6) CDDP-NAC group, 7) CDDP-TAU group… CONTINUE READING

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