Synergistic modulation by chloride and organic phosphates of hemoglobin from bear (Ursus arctos).

@article{Coletta1994SynergisticMB,
  title={Synergistic modulation by chloride and organic phosphates of hemoglobin from bear (Ursus arctos).},
  author={Massimiliano Coletta and Sarveri{\`o} G. Condo and Roberto Scatena and Maria Elisabetta Clementi and Simona Baroni and S N Sletten and Ole Brix and Bruno Giardina},
  journal={Journal of molecular biology},
  year={1994},
  volume={236 5},
  pages={1401-6}
}
The oxygen binding properties of hemoglobin (Hb) from brown bear (Ursus arctos) have been studied focussing on the effect of heterotropic ligands, and the behaviour has been compared with that of human HbA, taken as a prototype of mammalian Hbs. It has been observed that in bear Hb chloride ions and 2,3-diphosphoglyceric acid (Gri(2,3)P2) can modulate the oxygen affinity in a synergistic way such that their individual effect is enhanced whenever they are both present in saturating amounts. The… CONTINUE READING