Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.

@article{Rahim2015SynergisticKO,
  title={Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.},
  author={Nusaibah Abdul Rahim and Soon-Ee Cheah and Matthew David Johnson and Heidi Y. Yu and Hanna E Sidjabat and John D Boyce and Mark S Butler and Matthew A. Cooper and Jing Fu and David L Paterson and Roger L. Nation and Phillip John Bergen and Tony Velkov and Jian Li},
  journal={The Journal of antimicrobial chemotherapy},
  year={2015},
  volume={70 9},
  pages={
          2589-97
        }
}
OBJECTIVES Combination therapy is an important option in the fight against Gram-negative 'superbugs'. This study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin B and chloramphenicol combinations used against New Delhi metallo-β-lactamase (NDM)-producing MDR Klebsiella pneumoniae. METHODS Four NDM-producing K. pneumoniae strains were employed. The presence of genes conferring resistance to chloramphenicol was examined by PCR. Time-kill… CONTINUE READING
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