Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice

Abstract

Molecular targeting of cellular signaling pathways is a promising approach in cancer therapy, but often fails to achieve sustained benefit because of the activation of collateral cancer cell survival and proliferation pathways. We tested the hypothesis that a combination of targeted agents that inhibit compensatory pathways would be more effective than… (More)
DOI: 10.1007/s00280-013-2117-x

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