Synergistic interactions between cannabinoid and opioid analgesics.

@article{Cichewicz2004SynergisticIB,
  title={Synergistic interactions between cannabinoid and opioid analgesics.},
  author={D. Cichewicz},
  journal={Life sciences},
  year={2004},
  volume={74 11},
  pages={
          1317-24
        }
}
Cannabinoids and opioids both produce analgesia through a G-protein-coupled mechanism that blocks the release of pain-propagating neurotransmitters in the brain and spinal cord. However, high doses of these drugs, which may be required to treat chronic, severe pain, are accompanied by undesirable side effects. Thus, a search for a better analgesic strategy led to the discovery that delta 9-tetrahydrocannabinol (THC), the major psychoactive constituent of marijuana, enhances the potency of… Expand
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