Cannabinoid-opioid interactions during neuropathic pain and analgesia.
- BiologyCurrent opinion in pharmacology
The role of the cannabinoid system in opioid analgesia and tolerance.
- Biology, MedicineMini reviews in medicinal chemistry
The data indicating that with combining cannabinoids and opioids drugs may be able to produce long-term analgesic effects, while preventing the opioid analgesic tolerance are summarized.
Therapeutic potential of opioid/cannabinoid combinations in humans: Review of the evidence
- Biology, MedicineEuropean Neuropsychopharmacology
Molecular and cellular basis of cannabinoid and opioid interactions
- BiologyPharmacology Biochemistry and Behavior
Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain
- BiologyMolecular pain
Findings show that cannabinoid 2 receptor may functionally interact with mu-opioid receptor to modulate anti-nociception in the formalin test, and preliminary data suggest co-administration of JWH-133 with morphine modestly attenuates morphine tolerance.
Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
The alterations to the cAMP system seem to mirror the behavioral responses, indicating that the two systems may interact at the postreceptor level, which might open up new therapeutic opportunities for relief of chronic pain through cannabinoid–opioid coadministration.
Endocannabinoid system and opioid addiction: Behavioural aspects
- Biology, PsychologyPharmacology Biochemistry and Behavior
Endogenous Opioid and Cannabinoid Mechanisms Are Involved in the Analgesic Effects of Celecoxib in the Central Nervous System
- Medicine, BiologyPharmacology
The data provided further evidence for the involvement of endogenous opioids and revealed a new cannabinoid component of the mechanism(s) underlying celecoxib-induced analgesia in a model of inflammatory pain in rats, using the intracerebroventricular administration of selective opioid and cannabinoids.
Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia
Antinociception mechanisms of action of cannabinoid-based medicine: an overview for anesthesiologists and pain physicians
- Biology, MedicineRegional Anesthesia & Pain Medicine
This narrative review evaluates cannabinoids’ diverse mechanisms of action as it pertains to nociception modulation relevant to the practice of anesthesiologists and pain medicine physicians.
SHOWING 1-10 OF 65 REFERENCES
An analgesia circuit activated by cannabinoids
It is shown that a brainstem circuit that contributes to the pain-suppressing effects of morphine is also required for the analgesic effects of cannabinoids, and that cannabinoids are indeed centrally acting analgesics with a new mechanism of action.
Synergistic interactions of endogenous opioids and cannabinoid systems
- BiologyBrain Research
Cellular mechanism for anti-analgesic action of agonists of the κ-opioid receptor
In rats, κ-receptor activation in this brainstem nucleus significantly attenuates local μ-re receptor-mediated analgesia, suggesting a new cellular mechanism for the potentially ubiquitous opposing interaction between μ- and λ-opioid receptors and may help in the design of treatments for pain.
Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor.
- Biology, MedicineNature
In rats, kappa-receptor activation in this brainstem nucleus significantly attenuates local mu-recept-mediated analgesia, suggesting a new cellular mechanism for the potentially ubiquitous opposing interaction between mu- and kappa -opioid receptors and may help in the design of treatments for pain.
Pharmacological and biochemical interactions between opioids and cannabinoids.
- BiologyTrends in pharmacological sciences
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
- Biology, PsychologyThe Journal of Neuroscience
The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.
Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy
- BiologyThe Journal of Neuroscience
Two studies show that heterodimers exhibit distinct ligand binding and signaling characteristics, which may provide new foundations for more effective therapies.
Comparative characterization in the rat of the interaction between cannabinoids and opiates for their immunosuppressive and analgesic effects
- Biology, ChemistryJournal of Neuroimmunology
Spinal mechanisms ofΔ9-tetrahydrocannabinol-induced analgesia
- BiologyBrain Research