Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma

@article{Mohammad1998SynergisticIO,
  title={Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma},
  author={Ramzi M. Mohammad and George R. Pettit and V P Almatchy and Nathan R. Wall and Mary L. Varterasian and Ayad M. Ai-Katib},
  journal={Anti-Cancer Drugs},
  year={1998},
  volume={9},
  pages={149–156}
}
We studied the antitumor effects of dolastatin 10, its structural modification, auristatin PE (TZT-1027), and vincristine alone and in combination with bryostatin 1 on a human diffuse large cell lymphoma line (WSU-DLCL2) in vitro and in vivo. WSU-DLCL2 cells were cultured in RPMI 1640 at a concentration of 2 × 105/ml using a 24-well plate. Agents were added to triplicate wells, and cell count, viability, mitosis and apoptosis were assessed. Dolastatin 10 showed no apparent inhibition of cell… Expand
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