Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis.

@article{Luszczki2009SynergisticIO,
  title={Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis.},
  author={Jarogniew J Luszczki and Agnieszka Kolacz and Miroslaw Czuczwar and Krzysztof Przesmycki and Stanislaw J. Czuczwar},
  journal={European journal of pain},
  year={2009},
  volume={13 7},
  pages={
          665-72
        }
}
The aim of this study was to determine the analgesic effect of gabapentin and tiagabine - two antiepileptic drugs, administered alone and in combination at the fixed-ratio of 1:1, in two phases of the formalin test in mice. Log-probit analysis was used to evaluate dose-response effects and calculate the ED(50) values for gabapentin, tiagabine, and their combination at the fixed-ratio of 1:1 in the phases I and II of the formalin test in mice. The types of interactions between both antiepileptic… CONTINUE READING
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