Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.

@article{Cuadrado2002SynergisticIB,
  title={Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.},
  author={Antonio Cuadrado and Isabel de las Cuevas and Elsa Mar{\'i}a Valdiz{\'a}n and Juan Antonio Armijo},
  journal={European journal of pharmacology},
  year={2002},
  volume={453 1},
  pages={43-52}
}
We compared the effects of adding a non-protective dose of valproate to increasing doses of lamotrigine with those of monotherapy and vice versa in CD1 mice. Anticonvulsant effects were evaluated against seizures induced by both 4-aminopyridine and pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test. Changes in anticonvulsants, gamma-aminobutyric acid (GABA) and glutamate concentrations in the whole brain were also assessed. Lamotrigine increased the potency ratio of… CONTINUE READING

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