Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion.

@article{Harel1992SynergisticIB,
  title={Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion.},
  author={Zeev Harel and Gloria Shaffer Tannenbaum},
  journal={Endocrinology},
  year={1992},
  volume={131 2},
  pages={758-64}
}
Insulin-like growth factor (IGF)-I and -II peptides, receptors, mRNAs, and binding proteins are widely distributed in the central nervous system (CNS), yet their physiological role in the brain remains largely unknown. While earlier in vivo studies in the rat suggested that IGF-I may participate in feedback regulation of GH secretion at a CNS level, the preparations used were only partially pure. The recent availability of purified recombinant IGF-I and -II peptides prompted us to reexamine the… CONTINUE READING