Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer.

@article{Wang2000SynergisticIB,
  title={Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer.},
  author={Timothy C Wang and Charles A. Dangler and Darren Chi-Hsiang Chen and James R Goldenring and Theodore J. Koh and Raktima Raychowdhury and Robert J Coffey and Susumu Tokushima-shi Ito and A. Rodr{\'i}guez-Na Varro and Gj. Dockray and James G Fox},
  journal={Gastroenterology},
  year={2000},
  volume={118 1},
  pages={
          36-47
        }
}
BACKGROUND & AIMS Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined. METHODS The effects of hypergastrinemia, and possible synergy with Helicobacter felis infection, were investigated in insulin-gastrin (INS-GAS) transgenic mice. RESULTS INS-GAS mice initially showed mild hypergastrinemia, increased maximal gastric acid secretion, and increased… CONTINUE READING
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