• Medicine
  • Published in Cancer research 1985

Synergistic interaction between hydroquinone and acetaldehyde in the induction of sister chromatid exchange in human lymphocytes in vitro.

@article{Knadle1985SynergisticIB,
  title={Synergistic interaction between hydroquinone and acetaldehyde in the induction of sister chromatid exchange in human lymphocytes in vitro.},
  author={S A Knadle},
  journal={Cancer research},
  year={1985},
  volume={45 10},
  pages={
          4853-7
        }
}
Hydroquinone, a metabolite of benzene, and acetaldehyde, a metabolite of ethanol, induce sister chromatid exchanges (SCEs) at relatively high concentrations. Because both compounds are reported to form glutathione conjugates, experiments were carried out to see if there was a synergistic effect when lower concentrations of both chemicals were added to human lymphocyte cultures. Hydroquinone (40 microM) increased SCEs in some individuals but not in others. However, the rate of SCE was more than… CONTINUE READING

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