Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation.

@article{Fogli2013SynergisticIB,
  title={Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation.},
  author={Stefano Fogli and Fabio Stefanelli and Luca Picchianti and Marzia Del Re and V. Mey and Claudio Bardelli and Romano Danesi and Maria Cristina Breschi},
  journal={British journal of pharmacology},
  year={2013},
  volume={168 1},
  pages={266-75}
}
BACKGROUND AND PURPOSE An important objective in asthma therapy is to prevent the accelerated growth of airway smooth muscle cells which leads to hyperplasia and bronchial hyperreactivity. We investigated the effect of combination of salbutamol and PPARγ agonists on growth factor-stimulated human bronchial smooth muscle cell (BSMC) proliferation. EXPERIMENTAL APPROACH Synergism was quantified by the combination index-isobologram method. Assays used here included analyses of growth inhibition… CONTINUE READING
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