Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali

@article{Kim2001SynergisticIA,
  title={Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali},
  author={Yangmi Kim and Hyoweon Bang and Carmen Gnatenco and Donghee Kim},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={442},
  pages={64-72}
}
TRAAK is a member of the tandem-pore K+ channel family, and is expressed mainly in the brain. Using rat TRAAK (rTRAAK), we studied its single-channel kinetics, interactive modes of activation, and the role of the C-terminus on its pressure-, fatty-acid- and pH-sensitivity. When expressed in COS-7 cells, rTRAAK showed a mildly inwardly rectifying single-channel current/voltage relationship in symmetrical 140 mM KCl. Unlike TREK-1 and TREK-2, which are activated by acidic conditions, rTRAAK was… CONTINUE READING
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Cloning and expression of human TRAAK , a polyunsaturated fatty acids - activated and mechano - sensitive K ( + ) channel

  • P Lipton
  • FEBS Lett
  • 2000

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