Synergistic inhibition of synaptic signaling in cortical cultures by subcytotoxic levels of oligomerized amyloid-β and iron: alleviation by zinc.


Iron exacerbates amyloid-β (Aβ) toxicity, while zinc alleviates it. We examined the impact of these metals on Aβ-induced signaling inhibition. Murine embryonic cortical neurons on multi-electrode arrays received 0.1 μM FeCl2 0.1 μM zinc acetate and/or 10 nM oligomerized Aβ(1-42). No toxicity was observed. Spontaneous signaling was not altered by iron or A… (More)
DOI: 10.3233/JAD-132696


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