Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.

@article{Donadelli2007SynergisticIO,
  title={Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.},
  author={Massimo Donadelli and Chiara Costanzo and Stefania Beghelli and Maria Teresa Scupoli and Mario Dandrea and Antonio Bonora and Paolo Piacentini and Alfredo Budillon and Michele Caraglia and Aldo Scarpa and Marta Palmieri},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1773 7},
  pages={1095-106}
}
We investigated the ability of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) to interact with gemcitabine (GEM) in inducing pancreatic cancer cell death. The combined treatment with TSA and GEM synergistically inhibited growth of four pancreatic adenocarcinoma cell lines and induced apoptosis. This effect was associated with the induction of reactive oxygen species (ROS) by GEM, increased expression of the pro-apoptotic BIM gene by both TSA and GEM and downregulation of the 5… CONTINUE READING
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Trichostatin A

  • M. Donadelli, C. Costanzo, +5 authors M. Palmieri
  • an inhibitor of histone deacetylases, strongly…
  • 2003
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