Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha.

@article{Tanabe2004SynergisticIO,
  title={Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha.},
  author={Yoko Tanabe and Naoya Sakamoto and Nobuyuki Enomoto and Masayuki Kurosaki and Eri Ueda and Shinya Maekawa and Tsuyoshi Yamashiro and Mina Nakagawa and Cheng-Hsin Chen and Nobuhiko Kanazawa and Sei Kakinuma and Mamoru Watanabe},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 7},
  pages={1129-39}
}
Treatment of hepatitis C virus (HCV) infection with interferon (IFN)- alpha and ribavirin combination therapy results in superior clinical antiviral responses than does monotherapy with IFN. To explore the virological basis of the effects of combination therapy, we analyzed the effects of IFN- alpha and ribavirin, singly and in combination, on intracellular HCV replication by use of an HCV replicon system. A new replicon that expressed a selectable chimeric reporter protein comprising firefly… CONTINUE READING