Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin.

@article{Lin2010SynergisticII,
  title={Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin.},
  author={Tian Xin Lin and Young Ho Kwak and Fatima Y Sammy and Ping He and Sujatha R Thundivalappil and Guangjie Sun and Wei Chun Chao and Howland Shaw Warren},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 4},
  pages={
          624-32
        }
}
Detection of microbial components by immune cells via Toll-like receptors (TLRs) with subsequent induction of inflammation is essential for host defense. However, an overactive immune response can cause tissue damage and sepsis. The endogenous molecule hemoglobin and its derivative heme are often released into tissue compartments where there is infection in the presence of degrading blood. We found that hemoglobin synergizes with multiple TLR agonists to induce high levels of tumor necrosis… CONTINUE READING

Citations

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Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

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Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus

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Hemopexin in severe inflammation and infection: mouse models and human diseases

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