Synergistic induction of the MUC4 mucin gene by interferon-γ and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways

@article{Andrianifahanana2005SynergisticIO,
  title={Synergistic induction of the MUC4 mucin gene by interferon-γ and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways},
  author={Mahefatiana Andrianifahanana and Anshu Agrawal and Ajay Singh and Nicolas Moniaux and Isabelle van Seuningen and J D Aubert and Jane Meza and Surinder K Batra},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={6143-6154}
}
The transmembrane mucin, MUC4, is aberrantly expressed with a high incidence in human pancreatic adenocarcinomas and plays an important role in the pathogenesis of the disease. Our recent studies have shown that interferon-γ (IFNγ) and retinoic acid (RA) are important regulators of MUC4 in pancreatic tumour cells. Induction of MUC4 by IFNγ occurs via a novel pathway involving upregulation of the signal transducer and activator of transcription 1 (STAT-1), whereas its stimulation by RA requires… CONTINUE READING

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