Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

@inproceedings{Kaur2010SynergisticIO,
  title={Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss},
  author={Kirren Kaur and R. H. Stephen Hardy and M. Monjur Ahasan and Marco Eijken and Johannes P T M van Leeuwen and Andrew Filer and A. M. Thomas and Karim Raza and Christopher D Buckley and P. M. Stewart and Elizabeth H. Rabbitt and Martin Hewison and Mark Stuart Cooper},
  booktitle={Annals of the rheumatic diseases},
  year={2010}
}
OBJECTIVES Synovial fibroblasts and osteoblasts generate active glucocorticoids by means of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme. This activity increases in response to proinflammatory cytokines or glucocorticoids. During inflammatory arthritis synovium and bone are exposed to both these factors. This study hypothesised that glucocorticoids magnify the effects of inflammatory cytokines on local glucocorticoid production in both synovium and bone. METHODS The… CONTINUE READING
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