Synergistic induction of delta-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase.

@article{Cable1991SynergisticIO,
  title={Synergistic induction of delta-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase.},
  author={Edward Earl Cable and John F. Healey and Y J Greene and Chheng-Orn Evans and Herbert L. Bonkovsky},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1080 3},
  pages={
          245-51
        }
}
Relationships between activities of delta-aminolevulinate synthase and heme oxygenase, respectively the rate-limiting enzymes of heme biosynthesis and degradation, have been studied in chick embryo liver cell cultures following exposure of the cultures to glutethimide and iron, a combination known to produce a synergistic induction of both enzymes. In time-course experiments, synergistic induction of heme oxygenase activity by glutethimide and iron preceded that of delta-aminolevulinate… Expand
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TLDR
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Repression of ALA synthase by heme and zinc‐mesoporphyrin in a chick embryo liver cell culture model of acute porphyria
TLDR
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TLDR
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TLDR
A down-regulation of the intracellular machinery required for heme-dependent induction of heme oxygenase-1 is suggested, suggesting a short-lived protein plays a key role in modulating heme Oxygenase1 mRNA levels. Expand
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