Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs.

@article{Lovat2000SynergisticIO,
  title={Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs.},
  author={Penny E. Lovat and Marco Ranalli and Francesca Bernassola and Michael T Tilby and Archie J. Malcolm and Andrew D. J. Pearson and Mauro Piacentini and Gerry Melino and Christopher P. F. Redfern},
  journal={International journal of cancer},
  year={2000},
  volume={88 6},
  pages={977-85}
}
Retinoic acid therapy improves the survival of children with neuroblastoma and 13-cis retinoic acid now forms an important component of treatment for residual disease of stage IV neuroblastoma after chemotherapy. However, although 13-cis retinoic acid induces differentiation, other retinoids are effective at inducing apoptosis of neuroblastoma in vitro, including the novel compounds fenretinide and CD437 and these may be alternative retinoids for neuroblastoma therapy. The aim of our study was… CONTINUE READING
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