Synergistic induction of alkaline phosphatase in colonic carcinoma cells by sodium butyrate and hyperosmolality.

Abstract

Exposing HT-29 cells to the combination of two inducers of intestinal alkaline phosphatase, sodium butyrate and hyperosmolality, causes a synergistic (over 1000-fold) increase in specific activity. Evidence is presented showing that enzyme induction is reversible; the half-life of the induced activity is approximately 30 h. Preinduction by butyrate or by… (More)

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