Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes

@article{Follo2011SynergisticIO,
  title={Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes},
  author={Matilde Yung Follo and Carlo Finelli and Sara Mongiorgi and Cristina Clissa and Francesca Chiarini and Giulia Ramazzotti and Stefania Paolini and Giovanni Martinelli and Alberto Maria Martelli and Lucio Cocco},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={271-280}
}
The association between azacitidine (AZA) and valproic acid (VPA) has shown high response rates in high-risk myelodysplastic syndromes (MDS) cases with unfavorable prognosis. However, little is known about the molecular mechanisms underlying this therapy, and molecular markers useful to monitor the disease and the effect of the treatment are needed. Phosphoinositide-phospholipase C (PI-PLC) β1 is involved in both genetic and epigenetic mechanisms of MDS progression to acute myeloid leukemia… CONTINUE READING

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