Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat.

@article{ElHage2005SynergisticII,
  title={Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat.},
  author={Nazira El-Hage and Julie A Gurwell and Indrapal N. Singh and Pamela E Knapp and Avindra Nath and Kurt F Hauser},
  journal={Glia},
  year={2005},
  volume={50 2},
  pages={91-106}
}
Recent evidence suggests that injection drug users who abuse heroin are at increased risk of CNS complications from human immunodeficiency virus (HIV) infection. Opiate drugs may intrinsically alter the pathogenesis of HIV by directly modulating immune function and by directly modifying the CNS response to HIV. Despite this, the mechanisms by which opiates increase the neuropathogenesis of HIV are uncertain. In the present study, we describe the effect of morphine and the HIV-1 protein toxin… CONTINUE READING