Synergistic immunosuppressive effects of the mTOR inhibitor sirolimus and the phytochemical curcumin.

@article{Deters2013SynergisticIE,
  title={Synergistic immunosuppressive effects of the mTOR inhibitor sirolimus and the phytochemical curcumin.},
  author={Michael Deters and Heiko H{\"u}tten and Volkhard Kaever},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2013},
  volume={20 2},
  pages={120-3}
}
The immunosuppressant sirolimus and curcumin, the main principle of the turmeric spice, have shown antiproliferative effects on many human and not-human cell lines. Whereas the antiproliferative effect of sirolimus is mainly mediated by inhibition of mTOR, curcumin is described to affect many molecular targets which makes it unpredictable to appraise if the effects of these both substances on cell proliferation and especially on immunosuppression are additive or synergistic. To answer this… CONTINUE READING