Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.

Abstract

The chimeric bcr-abl tyrosine kinase is of crucial pathogenic importance in chronic myeloid leukemia (CML). As shown, bcr-abl activates the ras pathway by phosphorylation of adapter proteins such as Grb-2 and Crkl. Functional inhibition of p21ras might partially inhibit the mitogenic signaling by bcr-abl. By depletion of cellular mevalonate pools, p21ras… (More)

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Cite this paper

@article{MllerTidow2003SynergisticGI, title={Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.}, author={Carsten M{\"u}ller-Tidow and Michael G. Kiehl and Juergen Reinhard Sindermann and Michael Probst and Nicola Banger and Michael Zuehlsdorf and T. T. Chou and Wolfgang E. Berdel and Hubert Serve and Olaf Manfred Koch}, journal={International journal of oncology}, year={2003}, volume={23 1}, pages={151-8} }