Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2

@article{Kitagawa2010SynergisticGI,
  title={Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2},
  author={Jun-ichi Kitagawa and Takeshi Hara and Hisashi Tsurumi and Soranobu Ninomiya and Kengo Ogawa and Seiji Adachi and Nobuhiro Kanemura and Senji Kasahara and Masahito Shimizu and Hisataka Moriwaki},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2010},
  volume={137},
  pages={779-787}
}
The aim of this study was to assess the effects of acyclic retinoid (ACR) and vitamin K2 (VK2) in HL-60 cells. We used HL-60 cells, and the Trypan Blue dye exclusion method was used for cell proliferation assays. For detection of apoptosis, the Annexin V–binding capacity of treated cells was examined by flow cytometry. To evaluate the cell cycle, we used a… CONTINUE READING