Synergistic expression of the CXCL10 gene in response to IL-1β and IFN-γ involves NF-κB, phosphorylation of STAT1 at Tyr701, and acetylation of histones H3 and H4.

@article{Burke2013SynergisticEO,
  title={Synergistic expression of the CXCL10 gene in response to IL-1β and IFN-γ involves NF-κB, phosphorylation of STAT1 at Tyr701, and acetylation of histones H3 and H4.},
  author={Susan J Burke and Matthew Ray Goff and Danhong Lu and David Proud and Michael D. Karlstad and J. Jason Collier},
  journal={Journal of immunology},
  year={2013},
  volume={191 1},
  pages={323-36}
}
The CXCL10 gene encodes a peptide that chemoattracts a variety of leukocytes associated with type 1 and type 2 diabetes. The present study was undertaken to determine the molecular mechanisms required for expression of the CXCL10 gene in response to IL-1β and IFN-γ using rat islets and β cell lines. IL-1β induced the expression of the CXCL10 gene and promoter activity, whereas the combination of IL-1β plus IFN-γ was synergistic. Small interfering RNA-mediated suppression of NF-κB p65 markedly… CONTINUE READING