Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol.

  title={Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol.},
  author={Yeu-Chun Kim and Jung-hwan Park and Peter J. Ludovice and Mark R. Prausnitz},
  journal={International journal of pharmaceutics},
  volume={352 1-2},
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery of fluorescein across human cadaver epidermis was increased by up to 47-fold using formulations containing NLS in aqueous ethanol solutions. Skin permeability was increased by… CONTINUE READING

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