Synergistic encapsulation of the anti-HIV agent efavirenz within mixed poloxamine/poloxamer polymeric micelles.

@article{Chiappetta2011SynergisticEO,
  title={Synergistic encapsulation of the anti-HIV agent efavirenz within mixed poloxamine/poloxamer polymeric micelles.},
  author={Diego Andr{\'e}s Chiappetta and Graciela B. Facorro and Emilio Rub{\'i}n de Celis and Alejandro Sosnik},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2011},
  volume={7 5},
  pages={624-37}
}
This study investigated the synergistic performance of mixed polymeric micelles made of linear and branched poly(ethylene oxide)-poly(propylene oxide) for the more effective encapsulation of the anti-HIV drug efavirenz. The co-micellization process of 10% binary systems combining different weight ratios of a highly hydrophilic poloxamer (Pluronic F127) and a more hydrophobic poloxamine counterpart (Tetronic T304 and T904) was investigated by means of dynamic light scattering, cloud point and… CONTINUE READING

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