Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria.

@article{Sicouri2010SynergisticEA,
  title={Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria.},
  author={Serge Sicouri and Alexander Burashnikov and Luiz Belardinelli and Charles Antzelevitch},
  journal={Circulation. Arrhythmia and electrophysiology},
  year={2010},
  volume={3 1},
  pages={88-95}
}
BACKGROUND Amiodarone and ranolazine have been characterized as inactivated- and activated-state blockers of cardiac sodium channel current (I(Na)), respectively, and shown to cause atrial-selective depression of I(Na)-related parameters. This study tests the hypothesis that their combined actions synergistically depress I(Na)-dependent parameters in atria but not ventricles. METHODS AND RESULTS The effects of acute ranolazine (5 to 10 micromol/L) were studied in coronary-perfused right… CONTINUE READING

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Atriumselective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine

  • A Burashnikov, JM Di Diego, AC Zygmunt, L Belardinelli, C. Antzelevitch
  • Circulation
  • 2007
Highly Influential
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Atrialselective effects of chronic amiodarone in the management of atrial fibrillation

  • A Burashnikov, JM Di Diego, S Sicouri, M Ferreiro, L Carlsson, C. Antzelevitch
  • Heart Rhythm
  • 2008

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