Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus

@article{Zhang2005SynergisticEO,
  title={Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus},
  author={T. A. Zhang and Adam W. Hendricson and Michael F. Wilkemeyer and Melanie J Lippmann and Michael E. Charness and Richard A. Morrisett},
  journal={Neuroscience},
  year={2005},
  volume={134},
  pages={583-593}
}
The L1 cell adhesion molecule has been implicated in ethanol teratogenesis as well as NMDAR-dependent long-term potentiation (LTP) of synaptic transmission, a process thought to be critical for neural development. Ethanol inhibits LTP at least in part by interacting with NMDA receptors. Ethanol also inhibits L1-mediated cell adhesion in a manner that is prevented by an octapeptide, D-NAPVSIPQ (D-NAP), as well as long chain alcohols such as 1-octanol. Here we analyzed the effects of D-NAP and 1… Expand
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