Synergistic effects of thalidomide and poly(ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice

@article{Kroeger1996SynergisticEO,
  title={Synergistic effects of thalidomide and poly(ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice},
  author={Hans Kroeger and Ralf Miesel and Annette Dietrich and Manuela Ohde and {\'E}va Rajnav{\"o}lgyi and Heinrich Ockenfels},
  journal={Inflammation},
  year={1996},
  volume={20},
  pages={203-215}
}
The present study investigates synergistic effects of the TNF-α inhibitor thalidomide and the poly(ADP-ribose) polymerase (PARP)-inhibitor nicotinic acid amide (NAA) in male DBA/1 hybrid mice suffering from type II collagen-induced arthritis. Parameters including the arthritis index, chemiluminescence and anti-collagen antibody titers were used for the assessment of disease activity: The disease courses demonstrated clearly an inhibitory effect of thalidomide. NAA inhibited established collagen… CONTINUE READING
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Influence of antagonists of poly(ADP-ribose) polymerase on the development of collagen II induced arthritis

  • KROGER, m. DIETRICH, M. OHDE, R. MIESEL
  • 1995
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