Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions.

@article{Broxmeyer1988SynergisticEO,
  title={Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions.},
  author={Hal E. Broxmeyer and Liwei Lu and Scott Cooper and Robert Tushinski and D Mochizuki and Berish Y. Rubin and Steven Gillis and Douglas E. Williams},
  journal={Journal of immunology},
  year={1988},
  volume={141 11},
  pages={3852-62}
}
Purified recombinant human B cell growth factor-1/IL-4 was evaluated, alone and in combination, with purified preparations of recombinant human (rhu) CSF or erythropoietin (Epo) for effects on colony formation by human bone marrow CFU-GM progenitor cells (GM) and burst forming unit-E progenitor cells. rhu IL-4 synergized with rhu G-CSF to enhance granulocyte colony formation, but had no effect on CFU-GM colony formation stimulated by rhu GM-CSF, rhu IL-3, or rhu CSF-1. Rhu IL-4 synergized with… CONTINUE READING