Synergistic effects of progesterone and oestradiol on rat LH subunit mRNA.

@article{Corbani1990SynergisticEO,
  title={Synergistic effects of progesterone and oestradiol on rat LH subunit mRNA.},
  author={Mal̈{\"i}th{\'e} Corbani and Raymond Counis and Ewa Wolińska-Witort and Gis{\'e}le D'Angelo-Bernard and Mohi{\'e}ddine Moumni and Marian Jutisz},
  journal={Journal of molecular endocrinology},
  year={1990},
  volume={4 2},
  pages={
          119-25
        }
}
The effects of oestradiol and progesterone on LH-subunit mRNA levels were investigated in ovariectomized rats. Four weeks after ovariectomy, rats were implanted with silicone elastomer capsules containing oestradiol and/or injected daily with progesterone in oil (5 mg/rat) for 8 days. The levels of pituitary mRNA encoding alpha and LH-beta were determined using direct hybridization with specific [32P]cDNA probes. After oestradiol implantation in ovariectomized rats, both alpha and LH-beta mRNA… Expand
Direct pituitary effects of estradiol and progesterone on luteinizing hormone release, stores, and subunit messenger ribonucleic acids.
TLDR
It is concluded that the combination of P4 and E2 is necessary for inhibition of GnRH-stimulated LH secretion, which is the result of changes in both LH-beta subunit mRNA concentrations and LH secretion. Expand
Progestin increases the expression of gonadotropins in pituitaries of male zebrafish.
TLDR
DHP participated in the regulation of neuroendocrine control of reproduction in male zebrafish, and exerted a Pgr-mediated direct stimulatory effect on fshb mRNA at pituitary level. Expand
Estradiol negatively regulates secretogranin II and chromogranin A messenger ribonucleic acid levels in the female rat pituitary but not in the adrenal.
TLDR
It is concluded that, in rats, ovarian factors regulate the pituitary SgII and CgA protein and mRNA steady-state levels while such factors are inefficient in the adrenal gland. Expand
Progesterone stimulates luteinizing hormone secretion by acting directly on the pituitary.
TLDR
It is indicated that a short exposure to physiological levels of P in the range of early luteal phase levels has a stimulatory effect on LH secretion by acting directly at the pituitary level. Expand
Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression.
TLDR
The data indicate that progesterone feedback at the level of the pituitary gonadotrope is likely to play a key role in differential production of the gonadotropin genes. Expand
Differential stability of mRNAs coding for α and gonadotropin β subunits in cultured rat pituitary cells
TLDR
Data establish that the three mRNAs coding for gonadotropin subunits have different stabilities although they share substantial homology, and suggest that specific motifs and protein factors may interact to determine mRNA stability. Expand
Hormonal interactions in progesterone regulation of gonadotropin gene expression
TLDR
Though, the studies did not show any significant impairment of fertility, they serve as preliminary data indicating trends towards lower reproductive function, such as lower number of litters and pups, as well as lower levels of circulating hormones. Expand
Facilitation or Inhibition of the Estradiol‐Induced Gonadotropin Surge in the Immature Rat by Progesterone: Regulation of GnRH and LH Messenger RNAs and Activation of GnRH Neurons
TLDR
It is likely that P acts in the facilitation model to trigger release of pre‐existing GnRH stores by altering synthesis or activity of neuro‐transmitters/neuropeptides involved in GnRH regulation and/or release of LH stores by altered, for example, pituitary responsiveness to GnRH (including self‐priming) and components of the LH secretory apparatus. Expand
Biosynthesis of gonadotropins in vivo.
TLDR
Thyroid hormones can enhance or diminish the pituitary levels of LH beta and FSH beta subunit mRNAs in female rats and inhibin, activin and follistatin were shown to be potent regulators of FSHbeta gene expression. Expand
Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors
TLDR
The studies indicate that ovarian hormones can modulate DYN in the MF pathway in a time-dependent manner, and suggest that hormonal effects on the DYN-containing MF pathway may be directly mediated by ERbeta and/or PR activation. Expand
...
1
2
...