Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells.

@article{Mitra1999SynergisticEO,
  title={Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells.},
  author={S. P. Mitra and R. Carraway},
  journal={Biochemical pharmacology},
  year={1999},
  volume={57 12},
  pages={
          1391-7
        }
}
  • S. P. Mitra, R. Carraway
  • Published 1999
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Since neurotensin is often co-stored with catecholamines and since it can excite the release of dopamine and norepinephrine, responses to this peptide might depend upon the activity of catecholaminergic systems. In this study, we used prostate cancer PC3 cells, which express neurotensin receptors and 12-adrenergic receptors, to demonstrate that neurotensin can potentiate the effects of isoproterenol on 3',5'-cyclic adenosine monophosphate (cAMP) formation and on inhibition of DNA synthesis… CONTINUE READING
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