Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations.

@article{Brebner2000SynergisticEO,
  title={Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations.},
  author={Karen Brebner and Shawn P Hayley and Robert M. Zacharko and Zul Merali and Hymie Anisman},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2000},
  volume={22 6},
  pages={566-80}
}
The proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) influence neuroendocrine activity, promote central neurotransmitter alterations, and induce a constellation of symptoms collectively referred to as sickness behaviors. These cytokines may also elicit anxiety and anhedonia, and have been associated with psychological disturbances in humans. In the present investigation, systemic IL-1beta and TNF-alpha dose-dependently and synergistically… CONTINUE READING