Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen.

  title={Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen.},
  author={Mark P Ohan and Kevin S Weadock and Michael G. Dunn},
  journal={Journal of biomedical materials research},
  volume={60 3},
Our objective was to strengthen and stabilize collagen films without the introduction of cytotoxic chemical crosslinkers. We hypothesized that collagen could be rapidly crosslinked with glucose with ultraviolet (UV) irradiation as a catalyst. In theory, UV-generated free radicals can expedite collagen crosslinking with glucose via the formation of reactive, linear glucose molecules. The mechanical properties of glucose-incorporated, UV-exposed collagen films and appropriate controls were… CONTINUE READING

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