Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen.

@article{Ohan2002SynergisticEO,
  title={Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen.},
  author={Mark P Ohan and Kevin S Weadock and Michael G. Dunn},
  journal={Journal of biomedical materials research},
  year={2002},
  volume={60 3},
  pages={384-91}
}
Our objective was to strengthen and stabilize collagen films without the introduction of cytotoxic chemical crosslinkers. We hypothesized that collagen could be rapidly crosslinked with glucose with ultraviolet (UV) irradiation as a catalyst. In theory, UV-generated free radicals can expedite collagen crosslinking with glucose via the formation of reactive, linear glucose molecules. The mechanical properties of glucose-incorporated, UV-exposed collagen films and appropriate controls were… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 35 references

Skin photosensitizing agents and the role of reactive oxygen species in photoaging.

Journal of photochemistry and photobiology. B, Biology • 1992
View 9 Excerpts
Highly Influenced

Advanced glycation end products induce crosslinking of collagen in vitro

GB Sajithal, P Chithra, G. Chandrakasan
Biochim Biophys Acta • 1998

Biomaterial science: An introduction to materials in medicine

BD Ratner, AS Hoffman, FJ Schoen, JE Lemons, editors
Yannas IV. Natural materials • 1996

Evaluation of different chemical methods for cross-linking collagen gel, films and sponges

I Rault, V Frei, D Herbage, N Abdul-Malak, A. Huc
J Mater Sci Mater Med • 1996

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