Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal pigment epithelial cells.

@article{Nagineni1994SynergisticEO,
  title={Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal pigment epithelial cells.},
  author={Chandrasekharam N. Nagineni and Barbara Detrick and John J. Hooks},
  journal={Clinical and diagnostic laboratory immunology},
  year={1994},
  volume={1 5},
  pages={569-77}
}
The retinal pigment epithelial (RPE) cell is a potent regulatory cell within the retina. It helps to maintain normal retinal activity, and following gamma interferon (IFN-gamma) exposure, it may express major histocompatibility complex class II molecules and function as an antigen-presenting cell. Since interleukin-1 (IL-1) and IL-6 are potent cytokines observed in ocular inflammatory processes, we initiated studies to evaluate conditions which enable RPE cells to produce these cytokines… CONTINUE READING

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