Synergistic effects of feeding and dexamethasone on serum leptin levels.

  title={Synergistic effects of feeding and dexamethasone on serum leptin levels.},
  author={Blandine Laferr{\`e}re and Susan K. Fried and Kelly Hough and Samantha A Campbell and Jennifer Thornton and F. Xavier Pi-Sunyer},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={83 10},
The objectives of this study were to determine the time course of the stimulatory effect of dexamethasone on serum leptin and whether it depends on food intake. Dexamethasone (4mg) was administered I.V. over 1 minute to healthy human volunteers (n=8) under fasting and feeding conditions (2000 kcal given at three meals over 7 hours). At 10 hours, serum leptin levels were increased only in the fed subjects (delta leptin 10.6+/-1.6 vs -2.4+/-1.9 ng/ml, p=0.01, n=8). To assess the interactive… CONTINUE READING

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