Synergistic effects of dexamethasone on platelet-derived growth factor mitogenesis in vitro.

@article{Rutherford1992SynergisticEO,
  title={Synergistic effects of dexamethasone on platelet-derived growth factor mitogenesis in vitro.},
  author={Robert B. Rutherford and Mark D. Trailsmith and Maria Emanuel Ryan and Marc F Charette},
  journal={Archives of oral biology},
  year={1992},
  volume={37 2},
  pages={
          139-45
        }
}
Platelet-derived growth factor (PDGF) and insulin-like growth factor-I (IGF-I) interact to stimulate proliferation of fibroblasts in culture. Glucocorticoids variably effect the response of cultured fibroblasts to polypeptide growth factors. This study determined the effects of dexamethasone on growth-factor stimulation of gingival, periodontal ligament and pulp fibroblast proliferation in vitro. Cultures of quiescent, low-passage, human fibroblasts were treated for varying periods of time with… CONTINUE READING
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