Synergistic effects of cocaine and dizocilpine (MK-801) on brain stimulation reward.

Abstract

The rewarding effects of lateral hypothalamic electrical stimulation were assessed in animals treated with the combination of cocaine and dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate antagonist. Eight male Long-Evans rats were trained to perform a lever-press operant to deliver trains of cathodal rectangular pulses directly into the lateral… (More)

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